After much research by musicologists, there's at least been some light shed on Wiley's life. It was found from her cousin, Herbert Wiley, of Oxford, MS, that Wiley's family probably lived in South Carolina during her childhood, perhaps travelling between there and Oxford (as she was later buried in Oxford with some of her other family).
Her untold story shows more signs in the 1920s. Apparently, Wiley and Papa Charlie McCoy, one of the first ever recorded blues musicians from the early 1920s, had something of a relationship. Perhaps they met while Wiley worked in travelling medicine shows around Mississippi. Probably working as a musician throughout the 1920s, by 1930 Wiley and her recording partner, Elvie Thomas, recorded for Paramount in March 1930 and a year later in March 1931. Even Thomas never saw Wiley again after 1933. Luckily though, those recordings remain to give a sense of her unique playing style and haunting songs.